Mar 31, 2020 the spleen is a fist sized organ located in the left upper quadrant of the abdomen. The nodules of white pulp are wellspaced and have germinal center formation. This page was last edited on 26 september 20, at 22. It is normally palpable in preterm infants, in 30% of normal, fullterm neonates, and in 5% to 10% of infants and toddlers. Spleen red pulp the red pulp is mainly filled with venous sinuses, which contain red blood cells and occasionally white blood cells. The red pulp mostly consists of terminal branches of the splenic artery which end in specialized capillaries known as sheathed capillaries. Nov 21, 2017 overview of histology of spleen useful for all healthcare students across the world medical.
Splenectomymassive enlargement of the spleen or with evidence of hypersplenism. How i diagnose and treat splenic lymphomas blood american. This lecture will provide an overview of the lymphoid structure and histology of key cells, vessels, structures and organs lymphoid organs, including the lymph nodes, spleen and thymus, as well as extranodal lymphoid tissues including mucosal associated lymphoid tissues malt. Spleen stained with azan to distinguish the stroma or connective tissue components from the parenchyma. Mar 31, 2020 the spleen is the largest organ of your lymphatic system, a subdivision of the immune system. Spleen, organ of the lymphatic system located in the left side of the abdominal cavity under the diaphragm, the muscular partition between the abdomen and the chest. Its network of trabeculae, blood vessels and lymphoid tissue provides an environment in which white blood cells lymphocytes proliferate while old damaged red blood cells erythrocytes are recycled. Histology of human tissue, show spleen infarction histology of human tissue, show central artery hyaline degeneration of spleen as seen under the microscope, 10x zoom. B schematic diagram of major known splenic anatomical subdivisions drawn based. Dec 11, 2011 hairy cell leukemia splenomegaly, pancytopenia, and neoplastic mononuclear cells in the peripheral blood and bone marrowadministration of purine analogues, as initialtreatment. On cut section, the spleen displays nodules of white cells termed white pulp distributed within a reddish, vascular mass termed the red pulp. As the lymph nodes are filters for the lymphatic circulation, the spleen is the primary filtering element. Spleen lien is the largest lymphoid tissue in the body and. It shows how the artery has a lymphoid sheath surrounding the artery, as it enters the spleen, with aggregations of secondary lymphoid tissue.
Spleen is a large lymphoid organ that performs two main functions. Note that the arrangement of the reticular fibers is quite. The spleen is located in the upperleft part of the abdomen. Completely intraperitoneal, except at the hilum, where splenic vessels enter exit, part of foregut anatomy of. It is structurally complex and has a number of different functions such as immunological monitoring of bloodborne antigens, storage of blood and destruction of aged or abnormal blood cells. Needle biopsy offers a minimally invasive means of investigating spleen pathology and can be used safely in skilled hands to sample diffuse. Its network of trabeculae, blood vessels and lymphoid tissue provides an environment in which. Schematic drawing visualising stromal cells, capillaries and the. Cells distributed throughout the body as single cells or aggregations of cells or nonencapsulated lymphatic nodules.
Deep profiling of mouse splenic architecture with codex. A spleen easily palpable below the costal margin in any child over the age of 34 years should be considered abnormal until proven otherwise. Pdf parasitic load and histological aspects in different regions of. The main focus of this article is the histological arrangement of the spleen. The spleen clears the blood of aged blood cells and foreign particles and is the site of immune reactions to bloodborne antigens. Learn spleen histology with free interactive flashcards. Thymus and spleen are represented in red, while lymph nodes are color coded in green. The spleen is the largest secondary lymphoid organ, is considered the draining site for compounds that are administered intravenously, and is therefore considered an important organ to evaluate for treatmentrelated lesions. Lymphatic organs lymph node, spleen, thymus, tonsil.
Files are available under licenses specified on their description page. Jan 21, 2018 in this video, i have tried to narrate the salient features of histology of the spleen. Media in category histology of spleen the following 17 files are in this category, out of 17 total. Sh lecture lymphatic structure and organs embryology. Also remove heinz bodies or other red blood cell inclusions peripheral blood has howelljolly bodies if no functional spleen is present white pulp. The spleen has a unique location, embryological development and histological structure that differs significantly from other lymphoid organs. The sinuses are lined by elongated, rodshaped endothelial cells. In contrast to the other organs we have seen so far, the spleen is not arranged into cortex and medulla.
It is attached to the greater curvature of the stomach by the gastrosplenic ligament. By the end of the lab, you should be able to describe and distinguish lymph nodules, tonsil, lymph nodes, thymus, and spleen using the criteria given in the table below. The spleen is an encapsulated organ that filters blood and immunologically monitors blood. Diagram of mouse thymus, spleen and lymph nodes the diagram below shows the locations of various lymphoid tissues in the mouse. Inside, the mass of splenic tissue is of two types, the red pulp and the white pulp, which do not separate into regions but intermingle and are. Spleen stock photos download 1,162 royalty free photos. This is everyones favorite organ, the spleen well, at least its my favorite. Pdf normal structure, function, and histology of the spleen. Histology of spleen 16 images normal spleen histology, image. By the end of the lab, you should be able to describe and distinguish lymph nodules, tonsil, lymph. Current diagnostic pathology 1997 4, 100105 1997 pearson professional ltd histology of the spleen. Histology photo album home album list last uploads last comments most viewed top rated my favorites search. Mar 03, 2011 however, even spleen histology is not free of diagnostic pitfalls, which lie in the possible occurrence of overlapping patterns of infiltration among different lymphoma entities and in the expression of aberrant immunophenotypes by neoplastic clones.
Forms sheaths of lymphoid cells around arteries periarteriolar lymphatic sheath, composed of t cells and lymphoid follicles b cells with surrounding mantle zone proliferating b cells and. Media in category histological schematic the following 200 files are in this category, out of 233 total. Jun 23, 2019 the spleen is the largest organ of the lymphatic system. Affordable and search from millions of royalty free images, photos and vectors. Schematic drawing of spleen showing sampling areas. The spleen is encased in a thick connectivetissue capsule. From the author the game ends when you get all 5 questions correct, or when you give up. The terminal vessels of the spleens arterial tree are the sheathed capillaries, which either enter directly into splenic sinusoids or empty openly into the spleens connective tissue. Like every other organ, the spleen consists of stroma and parenchyma. The spleen is, like the lymph nodes, a discriminatory filter. In this video, i have tried to narrate the salient features of histology of the spleen. The white pulp represents the sections of the spleen which are involved in immune responses to bloodborne microbes and are in many ways analogous to lymph nodes.
The tissue can now be infiltrated with a suitable histological wax. Located in the upper left region of the abdominal cavity, the spleen s primary function is to filter blood of damaged cells, cellular debris, and pathogens such as bacteria and viruses. On the outer edge, note the presence of a capsule from which short trabeculae containing a trabecular artery and. It is structurally complex and has a number of different functions such. Cronic lymphocytic leukemiais a bcell leukemia that is characterized by the progressive accumulation of. The spleen is the largest secondary immune organ in the body and is responsible for initiating immune reactions to bloodborne antigens and for filtering the blood of foreign material and old or damaged red blood cells.
The white pulp, located around a central arteriole, is composed of the periarteriolar lymphoid. Choose from 171 different sets of spleen histology flashcards on quizlet. Each of these two functions is performed by specific compartments known as the white pulp and the red pulp respectively. Bridget wilkins is a clinical senior lecturer in pathology at southampton university and an honorary consultant histopathologist for the southampton university hospitals nhs trust. Spleen histology slide this is a histology slide of the spleen. The histology time software helps students learn anatomy and cell biology through a computerbased histology atlas of cells, tissues, and organs.
The spleen is the largest organ of your lymphatic system, a subdivision of the immune system. Images were captured by a leica dm 3000 optical microscope, leica dfc 320 digital camera, and leica im50 software. The spleen develops in association with the digestive system in the dorsal mesogastrium, and as the stomach rotates during development the spleen comes to occupy the left cranial abdomen. Normal structure, function, and histology of the spleen. I have tried to explain the identification points of the spleen. Images were captured by a leica dm 3000 optical microscope, leica dfc 320 digital camera, and leica im50. In this article we will discuss about the structure of spleen with the help of suitable diagram. Stroma a matrix of dense ct, type iii collagen, and some smooth muscle that make up a thin exterior capsule and interiorly projecting extensions of. Histological findings in spleens of dogs with visceral. It is the largest lymphoid organ and thus the largest filter of blood in the human body. Schematic representation of the main steps of the sl diagnostic workup. The two major functional zones of the spleen are the hematogenous red pulp and the lymphoid white pulp. It shows how the artery has a lymphoid sheath surrounding the artery, as it enters the. In the germinal centers and paracortical region, macrophages and dendritic cells trap and present antigens from lymph to b and t cells, initiating an immune response.
Find spleen stock images in hd and millions of other royaltyfree stock photos, illustrations and vectors in. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Similar in structure to a large lymph node, it acts primarily as a blood filter. The scarcity of capillaries inside the splenic white pulp is astonishing. One of the key structures of this system is the spleen. An ebook reader can be a software application for use on a computer such as microsofts free reader. Spleen lien is the largest lymphoid tissue in the body and specialised, beenshaped organ for filtering blood. Play this quiz called spleen histology and show off your skills. Structure of spleen with diagram lymphatic tissue biology. The spleen is not essential to life in adult individuals. In a sinus seen in crosssection the endothelial cells would extend out of the screen. The spleen is the organ charged with removing abnormal blood cells and making components of the immune system and is located above the stomach.
Like the thymus, the spleen houses and aids in the maturation of immune system cells called lymphocytes. Capillary networks and follicular marginal zones in human spleens. This is a section of the spleen showing the fibrous capsule at the surface and the red and white pulp regions within the organ. Note that the arrangement of the reticular fibers is quite distinct from say, oh a lymph node maybe. Enhanced histopathology of the spleen pubmed central pmc.
This diagrammatic representation of the spleen, should help you understand where red and white pulp come from. Histology is the study of the structure and function of the cells, tissue and organs of the human anatomy as viewed through a microscope. This open circulation is unique in the human circulatory system which is normally a closed circuit. The spleen is an organ found in virtually all vertebrates. The spleen sits in the peritoneal cavity on high under the rib cage on the left side. The reticuloendothelial system is an expansive network that encompasses the haematopoietic centres, the formed elements they produce, as well as the conduits that transports them. The database contains more than 5,000 light microscope. Spleen birte steiniger, university of marburg, marburg, germany the spleen is a secondary lymphoid organ present in all vertebrates. The spleen lies vertically on the left side of the cranial abdomen. Webpathology is a free educational resource with 10287 high quality pathology images of benign and malignant neoplasms and related entities. Histology software atlas for anatomy and cell biology study. Located in the upper left region of the abdominal cavity, the spleens primary function is to filter blood of damaged cells, cellular debris. The nodules of white pulp are wellspaced and have germinal. The spleen is the largest collection of lymphoid tissue in the body.
The spleen is a fist sized organ located in the left upper quadrant of the abdomen. The spleen can be a troublesome specimen for the surgical pathologist, not only because experience with the range of normal splenic histology is limited by its rarity but also because there is an often a. Capsule dense connective tissue enclosing the organ. The red pulp has a normal vascularity and does not appear to be expanded. Jun 12, 2011 spleen is an important internal organ that is on average not larger than the size of a fist. All structured data from the file and property namespaces is available under the creative commons cc0 license. Histology software atlas for anatomy and cell biology. I have tried to explain the identification points of the.
The spleen is the largest organ of the lymphatic system. Citations may include links to fulltext content from pubmed central and publisher web sites. Pubmed comprises more than 26 million citations for biomedical literature from medline, life science journals, and online books. Collagen fibers blue are restricted to the capsule. In humans it is about the size of a fist and is well supplied with blood. This is a quiz called spleen histology and was created by member mcnugget28. Name the lymphatic organs surrounded by connective tissue capsule. He has maintained an interest in splenic pathology, particularly lymphomas involving the spleen, for many years. Unlike the lymph nodes, the spleen is inserted into the blood stream. The goal of this lab is to examine the organization of the major organs of the lymphatic system.
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